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Journal of Clinical and Experimental
Hematopathology (JCEH)

Published on behalf of the Japanese Society for Lymphoreticular Tissue Research
and the Japanese Dendritic Cell Society

Print ISSN: 1346-4280
Online ISSN: 1880-9952



PRODUCT INFORMATION
Aims and Scope
  The Journal of Clinical and Experimental Hematopathology (JCEH) (the official journal of the Japanese Society for Lymphoreticular Tissue Research and Japanese Dendritic Cell Society) publishes articles describing laboratory and clinical investigations in hematolymphoid system and related field. The JCEH invites submissions under a broad scope of topics relevant to clinical and experimental hematolymphoid research and will consider manuscripts covering all aspects of hematopoiesis, red cells, lymphocytes, phagocytes, dendritic cells, immunobiology and pathophysiology of the hematolymphoid system, hematological malignancies, and transplantation. Manuscript categories include Original Articles, Case Studies, Short Communications, and Letters to the Editor written in English. Original Articles will be accepted for publication with the understanding that they have not been published or submitted elsewhere, and Reviews and Commentaries solicited by the Editor-in-Chief may also be published. For any investigation involving human subjects, informed consent must be obtained from the subject(s) and/or their guardian(s), and this must be clearly stated in the manuscript. Animal experiments should be performed according to the relevant guidelines for the care and use of laboratory animals.

Peer review processes
  Submitted manuscripts will be sent to peer reviewers. They will generally be reviewed by two experts with the aim of reaching a first decision as soon as possible. Statistical reviewers may be also used where required. Reviewers are asked to declare any competing interests and must agree to open peer review.
  Reviewers are asked whether the manuscript is scientifically sound and coherent, how interesting it is and whether the quality of the writing is acceptable. Where possible, the final decision is made on the basis that the peer reviewers are in accordance with one another, or that at least there is no strong dissenting view. In cases where there is strong disagreement either among peer reviewers or between the authors and peer reviewers, advice is sought from a member of the journal's Editorial Board. The journal allows a maximum of three revisions of any manuscript. The ultimate responsibility for editorial decisions lies with the Editor-in-Chief.

Readership
Hematologists / dermatologists / pathologists / histologists / epidemiologists / virologists / immunologists / oncologists / occupational and environmental health scientists

Keywords
Biology and Immunology of Hematolymphoid Tissues / Reactive, Infectious, and Lymphoproliferative Disorders / Laboratory Methodologies and Technologies / Lymphomas and Lymphoid Leukemias / Myeloma / Plasmacytoma / Lymphoproliferative Disorders (Other Than Overt Neoplasms) / Myeloid Leukemia, Myelodysplastic Syndrome, and Myeloproliferative Disorders / Histiocytic and Dendritic Cell Neoplasms / Non-hematolymphoid Neoplasms

Indexed/Abstracted in:
PubMed (NLM), Google

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EDITORIAL POLICY
Editor-in-Chief: Professor Mitsunori Yamakawa, Department of Pathological Diagnostics, Faculty of Medicine, Yamagata University, 2- 2- 2 Iida-Nishi, Yamagata 990- 9585, Japan.
  The Editor will review all material submitted for publication. Manuscripts that are considered to be of insufficient priority for publication will receive a prompt decision without further review. All other manuscripts are sent to two Editorial Board Members for peer review, and other expert consultants as needed. Peer reviewer identities are kept confidential. Author identities are not kept confidential. All accepted manuscripts become the permanent property and may not be published elsewhere without written permission from the author(s) and the Academy.

EDITORIAL BOARD : Journal of Clinical and Experimental Hematopathology

EDITORIAL STAFF
Editor-in-Chief: Mitsunori Yamakawa (Yamagata, Japan)
Associate Editors: Masutaka Furue (Fukuoka, Japan) / Masahiro Imamura (Hokkaido, Japan) / Keiji Iwatsuki (Okayama, Japan) / Tomohiro Kinoshita (Aichi, Japan) / Makoto Naito (Niigata, Japan) / Shigeo Nakamura (Aichi, Japan) / Masao Seto (Aichi, Japan) / Hideaki Tahara (Tokyo, Japan) / Kazuo Tamura (Fukuoka, Japan) / Masafumi Taniwaki (Kyoto, Japan) / Kensei Tobinai (Tokyo, Japan) / Tadashi Yoshino (Okayama, Japan)
Editorial Office: Department of Pathological Diagnostics, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
TEL: +81-23-628-5237, FAX: +81-23-628-5240,
e-mail: myamakaw@med.id.yamagata-u.ac.jp
Managing Editors: Hirokazu Nakamine (Osaka, Japan) / Ritsuro Suzuki (Aichi, Japan) / Junji Suzumiya (Shimane, Japan) / Motoko Yamaguchi (Mie, Japan)
EDITORIAL BOARD
Masafumi Abe / Yuji Akiyama / Sadao Aoki / Naoko Asano / Naoe Goto / Hironori Haga / Yuko Hashimoto / Kazuhiko Hayashi / Shigeo Horiike / Hiroshi Inagaki / Koiti Inokuchi / Fumihiro Ishida / Kenji Ishizuka / Yasushi Isobe / Masafumi Ito / Koji Izutsu / Norimitsu Kadowaki / Masahiro Kami / Kennosuke Karube / Masaru Kojima / Hiroshi Kosugi / Shunichi Kumakura / Kunihiko Maeda / Yoshinobu Maeda / Dai Maruyama / Yasufumi Masaki / Akihiro Masuda / Itaru Matsumura / Toshihiko Matsuo / Ikuo Miura / Hiroshi Miwa / Yasushi Miyazaki / Takashi Murate / Kazuo Muroi / Hirokazu Nagai / Takashi Nakahara / Naoya Nakamura / Nozomi Niitsu / Michinori Ogura / Hiroshi Ohno / Koichi Ohshima / Yasunori Ohta / Kazuma Ohyashiki / Masataka Okamoto / Yoshito Sadahira / Naomi Sakashita / Takashi Sato / Yasuharu Sato / Marimo Sato-Matsushita / Kenichi Sawada / Kei Shimizu-Kohno / Kazuya Shimoda / Masaaki Suefuji / Katsushi Tajima / Yasushi Takamatsu / Akihiro Takeshita / Morishige Takeshita / Kengo Takeuchi / Motohiro Takeya / Jun-ichi Tamaru / Mitsune Tanimoto / Takanori Teshima / Arinobu Tojo / Naoto Tomita / Norifumi Tsukamoto / Kunihiro Tsukasaki / Atae Utsunomiya / Hideo Wada / Takashi Watanabe / Takahiro Yamauchi
INTERNATIONAL EDITORIAL BOARD
Frederick R. Appelbaum (USA) / James O. Armitage (USA) / John K. C. Chan (Hong Kong) / H. Joachim Deeg (USA) / Georges Delsol (France) / Michael Hummel (Germany) / Peter G. Isaacson (UK) / Elaine S. Jaffe (USA) / Ian K. McNiece (USA) / Hans K. Muller-Hermelink (Germany) / Sibrand Poppema (Netherlands) / Andreas Rosenwald (Germany) / Harald Stein (Germany) / Goerg Stingl (Austria) / Ih-Jen Su (Taiwan)
JOURNAL PRODUCTION:
The Office of Japanese Society for Lymphoreticular Tissue Research
Department of Pathology and Laboratory Medicine, Nagoya University Graduate School of Medicine,
65 Tsurumai-cho, Showa-ku, Nagoya 466- 8550, Japan
TEL: 052-744-2085 FAX: 052-744-2897
http://www.jsltr.org/journal/en/jceh_en.html

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INSTRUCTIONS FOR AUTHORS
  To read about how to prepare your article, please visit on Instruction to Authors. If you are ready to submit an article please click on Online Submission. Additional information and news can be found at Journal homepage (http://www.jsltr.org/journal/en/jceh_en.html).

Instruction to Authors
  The Journal of Clinical and Experimental Hematopathology (JCEH) invites submission of manuscripts under a broad scope of topics relevant to clinical and experimental hematolymphoid research and publishes Original Articles, Review Articles, Commentaries, Case Studies, Short Communications, and Letters to the Editor written in English.

TYPES OF ARTICLES
Original Articles
  Full research manuscripts should be as concise as possible, without sacrificing documentation of results. For studies on humans, a clear statement must be provided concerning informed consent, and that the study was conducted after Human Experimentation Review by the relevant committee. Original articles should fit within the categories described below and meet the editorial standards stated.
  The journal is pleased to offer a fast publication track for original articles presenting superior novel findings and for studies of greatest priority ranked against similar submissions. The “Fast Track” articles appear earlier than regular manuscripts. Fast Track manuscripts are chosen specifically by the editors according to their judgment and upon the recommendation of reviewers.

  • Biology and Immunology of Hematolymphoid Tissues
  • Reactive, Infectious, and Lymphoproliferative Disorders
  • Laboratory Methodologies and Technologies
  • Lymphomas and Lymphoid Leukemias
  • Myeloma/Plasmacytoma
  • Lymphoproliferative Disorders (Other Than Overt Neoplasms)
  • Myeloid Leukemia, Myelodysplastic Syndrome, and Myeloproliferative Disorders
  • Histiocytic and Dendritic Cell Neoplasms
  • Non-hematolymphoid Neoplasms

Review Articles
  Though these are primarily commissioned by the Editors, exceptionally, proposals will be considered and sent for peer review. Presubmission inquiries describing the proposed articles must be sent before submission. The Editors will then indicate whether the review is of potential interest for the journal.

Commentaries
  Commentaries present interesting and controversial topics in hematolymphoid research, hypotheses, methods and applications. They are meant to promote discussion and generate new ideas for further study.

Case Studies
  Case Studies concerning hematolymphoid diseases must provide new information. The journal is also pleased to offer short case study within two printed journal pages.

Short Communications
  Articles containing pertinent and interesting observations concerning hematolymphoid research in general and reports on new observations or studies that do not warrant publication as a full research article will be considered for the Short Communication section. These articles will undergo full peer review.

Letters to the Editor
  Comments on published papers and controversial issues, also including negative data that are of general interest or that contradict commonly accepted concepts or hypotheses, will be considered for publication as Letters to the Editor. In the former case, the Editors may invite letters containing pertinent and interesting observations concerning hematolymphoid research in general, reports on new observations or pilot studies that do not justify a full research article, or comments on published papers will be considered for publication. In the latter case, the Editors may invite the authors of the paper being questioned to respond. Both letters may then be published, if found to be of interest to the Editors.

PRESENTATION OF MANUSCRIPTS
  Articles should be written in English (American spelling).

Original Articles
  Original articles should be divided into following sections :
Title Page with author name(s) and affiliation(s), corresponding author contact information ― address, fax, and email ―, and a running title (less than 40 letters). Non-structured Abstract (maximum 250 words) with three to five unabbreviated keywords
・ Introduction ・ Materials and Methods ・ Results ・ Discussion ・ Acknowledgments ・ References ・ Tables ・ Figure Legends ・ Description of additional data file (if any)
  Please note that we cannot process your manuscript if the abstract or the references do not conform to JCEH style.

Review Articles
  Manuscript should not exceed 12,000 words in length (10 printed journal pages) plus figures and tables and approximately 80 references.

Commentaries
  Manuscript should not exceed 8,000 words in length (6 printed journal pages) plus figures and tables and approximately 50 references.

Case Studies
  Manuscript should not exceed 8,000 words in length (6 printed journal pages) plus figures and tables and approximately 50 references.

Short Communications
  Short Communications should begin with a title page (with the heading Short Communication and corresponding author contact information ― address, fax, and e-mail). Manuscript should not exceed 6,000 words in length.

Letters to the Editor
  Letters should begin with a title page (with the heading Letter to the Editor and corresponding author contact information ― address, fax, and e-mail). Manuscript should not exceed 4,000 words in length.

General Elements of Manuscripts
Sponsorship and Funding/Financial Disclosure

  The Acknowledgments section is an appropriate place to recognize coworkers, indicate funding sources, and disclose information about affiliations and potential conflicts of interest (for example, commercial affiliations, patent-licensing arrangements). Authors must state all their sources of funding and any other financial and personal relationships that might bias their work. If the research reported in the manuscript has received partial or complete funding from commercial sponsors, the authors must also include a statement to that effect. The Editors reserve the right not to consider a manuscript if a sponsor has asserted control over the authors' right to publish their research results. Therefore, if the authors have a potential financial or personal conflict of interest, they must submit the Conflict of Interest form.

Abbreviations
  The following abbreviations should be used : L, mL, dL, mL, kg, g, mg, mg, ng, pg, m, cm, mm, mm, nm, M (molar), mM (millimolar), Gy, ℃, mon, hr, min, sec, msec, etc. Other abbreviations should appear in parentheses immediately after first mention and may be used alone thereafter in the text.

Gene Names
  Please mark all gene names in italics. Only the gene names should be written in italics, to distinguish them from gene products, gene segments, clusters, families, complexes, or groups. Authors should only use the official gene name as assigned by the respective gene nomenclature committee.

References
  References are listed in a separate reference section immediately following the text. All references must be verified by the corresponding author who submits the manuscript to the JCEH. Follow the style of the “Uniform Requirements for Manuscripts Submitted to Biomedical Journals” for reference format and Index Medicus for standard journal abbreviations (please see examples below). Number references sequentially in the order cited in the text ; do not alphabetize. A reference cited only in a table or figure is numbered in the sequence established by the first mention in the text of the table or figure containing the reference.
  Reference to a personal communication or to a manuscript categorized as in preparation or submitted for publication is discouraged. However, if such a reference is essential and refers to a written communication, the source is cited parenthetically in the text (not in the reference section) with the comment “unpublished data” or “personal communication.” Written permission from the source that is cited must be sent to the Editorial Office. Reference to a manuscript accepted but not yet published is listed in the reference section as “in press.” “In press” references must be updated by the authors as soon as publication
data is available. Provide names of all authors in a reference when there are five or fewer ; if there are six or more authors, list the first five, followed byet al.” Journal references shall include the specified information listed in the following order : authors, article title and subtitle, journal abbreviation, volume number in Arabic numerals, inclusive pages, and year :

Popat U, Frost A, Liu E, Guan Y, Durette A, et al. : High levels of circulating CD34 cells, dacrocytes, clonal hematopoiesis, and JAK2 mutation differentiate myelofibrosis with myeloid metaplasia from secondary myelofibrosis associated with pulmonary hypertension. Blood 107 : 3486- 3488, 2006
Book references are listed as follows : authors, title, edition (if other than the first), volume (if more than one), city, publisher, pages, and year :

Lennert K, Feller AC : Histopathology of Non-Hodgkin's Lymphomas (Based on the Updated Kiel Classification). 2nd ed, Berlin, Springer-Verlag, pp. 1- 44, 1981
When referencing a book chapter, the order changes as follows : authors of the chapter, title of the chapter, “In :” editors/authors of the book, title of the book, edition (if there are more than one), volume (if there are more than one), city, publisher, inclusive pages of the chapter, and year :

Stossel TP : The molecular basis of white blood cell motility. In : Stamatoyannopoulos G, Nienhuis AW, Majerus PW, Varmus H (eds) : The Molecular Basis of Blood Diseases. 2nd ed, Philadelphia, Saunders, pp. 541- 562, 1994

Figures
  Authors should upload high-quality graphic data for figures. For use in the peer review process, the Editorial office can use PDF, DOC, PPT, TIF, and JPG files. Figures may be submitted in these formats. However, the preferred format is PPT, TIF, or JPG files, which would be required when the manuscript is accepted.

Electronic Supplementary Material
  Material that is not suitable for print publication such as very long tables, database information, etc. can be published online as electronic supplementary material. The final decision to do so, however, lies with the Editors. Please submit camera-ready files for this material as it will not be edited or altered in any way by the publisher.

EDITORIAL PROCESS
  All manuscripts are assessed initially by the editors. A selection of manuscripts is then sent for review to experts in the field. When a decision is reached, a decision letter is sent to the authors by e-mail with the comments of the referees. Decision letters for manuscripts not sent for review are also sent by email. To aid in the peer review, we invite authors to suggest potential reviewers of their manuscript (including affiliation, address, and e-mail) in the online submission procedure. The authors also have the option of naming non-preferred reviewers. Receipt of a manuscript is acknowledged by e-mail. We remind you that in submitting to JCEH you agree that your work is original in presentation and content and that the work has neither been published elsewhere ― including being posted on any site on the Internet ― nor is simultaneously under submission as a complete manuscript with another journal.

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ONLINE SUBMISSION
  Manuscripts must be submitted by one of the authors of the manuscript, and should not be submitted by anyone on their behalf. The submitting author takes responsibility for the article during submission and peer review. To facilitate rapid publication and to minimize administrative costs, JCEH receives only online submission.

New Submissions
  Please submit all new manuscripts online. Individual files should be uploaded for the text (PDF or DOC format), tables (PDF or DOC for text), and figures (PPT, TIF, or JPG). You do not need to mail any copies. Launch your web browser and go to http://ess.jstage.jst.go.jp/contrib/jslrt/initialsubmission/for Japanese author(s) or http://ess.jstage.jst.go.jp/contrib/jslrt/initialsubmission/-char/en for non-Japanese author(s).
  Please create a new account on submission. Follow the step-by-step instructions. Please note that the manuscript should be submitted by or on behalf of the corresponding author. At the end of a successful submission, a confirmation screen with a manuscript number will appear and you will receive an e-mail confirming that the manuscript has been received by the journal and you will find out your new Login ID (Manuscript Number or Submission Number) and password. If this does not happen, please check your submission.
  To visit your submission again you need go to http://ess.jstage.jst.go.jp/contrib/jslrt/main/-char/ja for Japanese author(s) or http://ess.jstage.jst.go.jp/contrib/jslrt/main/-char/en for non-Japanese author(s), and input with new ID Number and password.
  Please contact the Editorial Office by e-mail regarding specific requirements. 

Required Documents for New Submissions
  For new submissions we require the following documents, which can be uploaded as a PDF or DOC file to the web or sent to us by e-mail. They can be submitted by e-mail, or uploaded to the web site along with the manuscript.
Covering Letter. Please introduce your work in a covering letter with addressing the aim of the study, the significant and novel findings, and the relationship to the present state of the field.
Submission Form. The Journal requires the consent of all authors upon submission, verifying agreement with content and presentation, and knowledge of submission to JCEH. Each author who has conflict of interest must submit the Conflict of Interest form. The manuscript cannot be processed until these forms are complete.
Letter of Permission. Permission is required from the appropriate investigators when “personal communication” or “unpublished data” is cited in the manuscript or from the publisher if previously published material has been used in the manuscript.

Submission of Revised Manuscripts
  If you have been invited to submit a revised manuscript, please re-submit it online via
http://ess.jstage.jst.go.jp/contrib/jslrt/main/-char/ja for Japanese author(s) or http://ess.jstage.jst.go.jp/contrib/jslrt/main/-char/en for non-Japanese author(s) with new ID Number and password, which you already received by e-mail after initial submission.
  Instructions can be found there : Enter your point-by-point responses to the reviewers separately in the Response File. Upload two versions of the revised manuscript, one clean copy and another with all changes underlined or marked. Please also re-upload figures and tables.


EDITORIAL DECISIONS
Rejected Manuscripts
  Manuscripts may be rejected either based on the opinions of the Editors or based on the comments of reviewers. Manuscripts not reaching a high enough level of priority or not fitting within the scope of the Journal will be returned to authors without detailed comments. Only manuscripts of high priority will be considered.

Revisions Requested
  If the Editors and the reviewers respond positively to a manuscript and are interested in considering it further after additional work is included, authors will be invited to resubmit the manuscript to JCEH. A decision letter will be sent by e-mail containing the comments of the reviewers. We ask that revisions are made within 3 months. Any questions concerning the requested changes/additional work should be addressed to the Editors by e-mail before submission of the revised manuscript. Revised manuscripts may be returned to the original reviewers for reassessment. Therefore, the review process of the revised manuscript may take over a month in some cases. The Editors maintain the option to reject a manuscript in a second or third round of revision if the specific concerns have not been met or if the manuscript still does not meet a high enough level of priority. Please always include the manuscript number in any correspondence and the submission documents.

Accepted Manuscripts
  When a manuscript is accepted for publication by the editors, it is sent to the publisher for typesetting, copy editing and printing. An electronic proof of the typeset and copy edited version will be sent to the author for approval. We ask that you report any changes immediately to the publisher. Manuscripts will be held in the editorial office if outstanding materials are required (accepted version of the manuscript and conflict of interest form if this has not been submitted previously). Electronic proofs may take approximately 8 weeks to generate. The publisher may be contacted with questions about proofs.
  Authors submitting articles to JCEH agree that, if accepted, the copyright of the article, including the right of reproduction in all forms and media, will belong exclusively to the Japanese Society of Lymphoreticular Tissue Research.


PUBLICATION AND TECHNICAL INFORMATION

Guidelines for Final Version of Accepted Manuscripts
  The final versions of accepted manuscripts (text, tables and figures) should be uploaded online.

Text
  Software and Format. Only Microsoft Word (DOC file) is available for the latest version, although manuscripts prepared with other operating systems and software may be accommodated. Do not use desktop publishing software such as Aldus PageMaker or Quark X Press. If you prepared your manuscript with one of these programs, including EndNote, please export the text to a word processing format.

Figures
  Authors should upload high-quality graphic data for figures. The required format is PPT, JPG, or TIF. All color figures will be reproduced in full color in the online edition of the journal at no cost to authors. Authors are requested to pay the cost of reproducing color figures in print. When necessary to convey essential scientific information authors are encouraged to submit color illustrations. For best reproduction, bright, clear colors should be used. Dark colors against a dark background do not reproduce well ; please place your color images against a white background wherever possible. All print reproduction requires files for full color images to be in a CMYK color space.

Software and Format.  All figures of accepted manuscripts should be in PPT, JPG or TIF format.
Resolution.  The minimum requirements for resolution are : 1,200 DPI/ PPI for black and white images, such as line drawings or graphs. 300 DPI/PPI for picture-only photographs 600 DPI/ PPI for photographs containing pictures and line elements, i.e., text labels, thin lines, and arrows. These resolutions refer to the output size of the file ; if you anticipate that your images will be enlarged or reduced, resolutions should be adjusted accordingly.
Color Art.  Resolution should be at least 300 DPI for all color figures. Files must be in CMYK format.

File names.  Illustration files should be named by the figure number and the 3- letter extension that identifies the file format used (i.e., .ppt, .jpg or.tif).

Charges
Page Charges

  There are no page charges to authors in principle. You should, however, pay ¥20,000 for your publication fees only when you do not order offprints.

Color Charges
  Please be aware that the cost of color printing will be incurred by the author. It costs ¥20,000 across the board independent of the number of color printing page.

English Language Charges   Authors are responsible for the linguistic accuracy of their manuscripts. The cost of English revision by the Language Consultant according to the extent of the revision will be charged to the author.

Offprints   Offprint order forms are sent to authors with their proofs, which should be used to order all offprints. The order form must be returned with the proofs. Late orders may be charged at higher rates (orders will not be processed if received after the issue has gone to press). Offprints are supplied at a rate based on the number of pages in the printed article and the number of offprints ordered. There is a minimum order quantity of 50 copies.

  Japanese contributors must pay not only a total due of page charges, color charges and offprints charges but also a 8%-consumption tax on a total due. Overseas contributors must remit 4,000 yen for a bank handling commission in addition to a total due of page charges, color charges, English language charges and offprints charges, and a 8%-consumption tax, by bank draft or a remittance check. The payment by credit card is not available.

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CONTACT INFORMATION
  We invite inquiries to the editorial office at any time during the editorial process. For all matters concerning presubmission, editorial policies and procedures, and general production matters, please contact the editorial office described below :

Address for Contact
Professor Mitsunori Yamakawa
Editor-In-Chief
Journal of Clinical and Experimental Hematopathology
Department of Pathological Diagnostics
Yamagata University School of Medicine
2-2-2 Iida-Nishi, Yamagata 999-9585, Japan
TEL: +81-23-628-5237
FAX: +81-23-628-5240
e-mail : myamakaw@med.id.yamagata-u.ac.jp

Electric Forms
Permission Request Form
Conflict of Interest Form
Offprint Order Form

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Copyright since 2003 (C) The Japanese Society for Lymphoreticular Tissue Research.
All rights reserved.